Hypomelanosis of Ito

Definition

Hypomelanosis of Ito (HMI) is a very rare birth defect that causes unusual patches of light-colored (hypopigmented) skin and may be associated with eye, nervous system, and skeletal problems.

Causes

Health care providers do not know the exact cause of HMI, but they believe it is a problem with genes. It is twice as common in girls than in boys.

Symptoms

Skin symptoms are most often visible by the time a child is about 2 years old.

Other symptoms develop as the child grows, and may include:

Exams and Tests

Ultraviolet light (Wood lamp) examination of the skin lesions may help confirm the diagnosis.

Tests that may be done include any of the following:

Treatment

There is no treatment for the skin patches. Cosmetics or clothing may be used to cover the patches. Seizures, scoliosis, and other problems are treated as needed.

Outlook (Prognosis)

Outlook depends on the type and severity of symptoms that develop. In most cases, skin color eventually turns to normal.

Possible Complications

Problems that may result from HMI include:

When to Contact a Medical Professional

Call your provider if your child has an unusual pattern of the color of the skin. However, any unusual patterns are likely to have another cause than HMI.


Review Date: 5/2/2017
Reviewed By: David L. Swanson, MD, Vice Chair of Medical Dermatology, Associate Professor of Dermatology, Mayo Medical School, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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