Waterhouse-Friderichsen syndrome (WFS) is a collection of symptoms resulting from the failure of the adrenal glands to function normally as a result of bleeding into the gland.
The adrenal glands are two triangle-shaped glands. One gland is located on top of each kidney. The adrenal glands produce and release different hormones that the body needs to function normally. The adrenal glands can be affected by many diseases, such as infections like WFS.
WFS is caused by severe infection with meningococcus bacteria or other severe infection from bacteria, such as:
Symptoms and signs usually come on very suddenly. They are due to the bacteria growing (multiplying) inside the body. Symptoms include:
Infection with bacteria causes bleeding throughout the body, which causes:
Bleeding into the adrenal glands causes adrenal crisis, in which not enough adrenal hormones are produced. This leads to symptoms such as:
The health care provider will perform a physical examination and ask about the person's symptoms.
Blood tests will be done to help confirm if the infection is caused by bacteria. Tests may include:
If the provider suspects the infection is caused by meningococcus bacteria, other tests that may be done include:
Tests that may be ordered to help diagnose acute adrenal crisis include:
Treatment involves giving antibiotics as soon as possible to treat the bacterial infection. Glucocorticoid medicines will also be given to treat adrenal gland problem. Supportive treatments will be needed for other symptoms.
WFS is fatal unless treatment for the bacterial infection is started right away and glucocorticoid drugs are given.
To prevent WFS caused by meningococcal bacteria, a vaccine is available.
Reviewed By: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.