A granuloma is a clump of cells that forms when the immune system tries to fight off a harmful substance but cannot remove it from the body.
A necrotizing granuloma is an area of inflammation in which tissue has died. Necrotizing means dying or decaying.
Tuberculosis and granulomatosis with polyangiitis are conditions that cause necrotizing granulomas.
Reviewed By: Debra G. Wechter, MD, FACS, general surgery practice specializing in breast cancer, Virginia Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.