CSF oligoclonal banding is a test to look for inflammation-related proteins in the cerebrospinal fluid (CSF). CSF is the clear fluid that flows in the space around the spinal cord and brain.
Oligoclonal bands are proteins called immunoglobulins. The presence of these proteins indicates inflammation of the central nervous system. The presence of oligoclonal bands may point to a diagnosis of multiple sclerosis.
A sample of CSF is needed. A lumbar puncture (spinal tap) is the most common way to collect this sample.
Other methods for collecting CSF are rarely used, but may be recommended in some cases. They include:
After the sample is taken, it is sent to a lab for testing.
This test helps support the diagnosis of multiple sclerosis (MS). However, it does not confirm the diagnosis. Oligoclonal bands in the CSF may also be seen in other illnesses such as:
Normally, one or no bands should be found in the CSF.
Note: Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.
The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.
There are two or more bandings found in the CSF and not in the blood. This may be a sign of multiple sclerosis or other inflammation.
Reviewed By: Amit M. Shelat, DO, FACP, FAAN, Attending Neurologist and Assistant Professor of Clinical Neurology, Stony Brook University School of Medicine, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.