Pleural biopsy is a procedure to remove a sample of the tissue lining the lungs and the inside of the chest wall to check for disease or infection.
This test may be done in the hospital. It may also be done at a clinic or doctor's office.
The procedure involves the following:
In some cases, pleural biopsy is done using a fiberoptic scope. The scope allows the doctor to view the area of the pleura from which the biopsies are taken.
You will have blood tests before the biopsy. You will likely have a chest x-ray.
When the local anesthetic is injected, you may feel a brief prick (like when an intravenous line is placed) and a burning sensation. When the biopsy needle is inserted, you may feel pressure. As the needle is being removed, you may feel tugging.
Pleural biopsy is usually done to find the cause of a collection of fluid around the lung (pleural effusion) or other abnormality of the pleural membrane. Pleural biopsy can diagnose tuberculosis, cancer, and other diseases.
If this type of pleural biopsy is not enough to make a diagnosis, you may need a surgical biopsy of the pleura.
Pleural tissues appear normal, without signs of inflammation, infection, or cancer.
Abnormal results may reveal cancer (including primary lung cancer, malignant mesothelioma, and metastatic pleural tumor), tuberculosis, other infections, or collagen vascular disease.
There is a slight chance of the needle puncturing the wall of the lung, which can partially collapse the lung. This usually gets better on its own. Sometimes, a chest tube is needed to drain the air and expand the lung.
There is also a chance of excessive blood loss.
If a closed pleural biopsy is not enough to make a diagnosis, you may need a surgical biopsy of the pleura.
Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.