Uterine sarcoma


Uterine sarcoma is a rare cancer of the uterus (womb). It is not the same as endometrial cancer, a much more common cancer that starts in the lining of the uterus. Uterine sarcoma most often starts in the muscle underneath that lining.


The exact cause is not known. But there are certain risk factors:


The most common symptom of uterine sarcoma is bleeding after menopause. Let your health care provider know as soon as you can about:

Most likely, the bleeding will not be from cancer. But you should always tell your provider about unusual bleeding.

Other possible symptoms of uterine sarcoma include:

Some of the symptoms of uterine sarcoma are similar to those of fibroids. The only way to tell the difference between sarcoma and fibroids is with tests, such as a biopsy of tissue taken from the uterus.

Exams and Tests

Your provider will take your medical history. You will also have a physical exam and a pelvic exam. Other tests may include:

Imaging tests are needed to create a picture of your reproductive organs. Ultrasound of the pelvis is often done first. Yet, it often cannot tell the difference between a fibroid and a sarcoma. An MRI scan of the pelvis may also be needed.

A biopsy using ultrasound or MRI to guide the needle may be used to make the diagnosis.

If your provider finds signs of cancer, other tests are needed for staging the cancer. These tests will show much cancer there is. They'll also show if it has spread to other parts of your body.


Surgery is the most common treatment for uterine cancer. Surgery may be used to diagnose, stage, and treat uterine sarcoma all at one time. After surgery, the cancer will be examined in a lab to see how advanced it is.

Depending on the results, you may need radiation therapy or chemotherapy to kill any cancer cells that remain.

You also may have hormone therapy for certain kinds of tumors that respond to hormones.

For advanced cancer that has spread outside the pelvis, you may want to join a clinical trial for uterine cancer.

With cancer that has come back, radiation may be used for palliative treatment. Palliative care is meant to relieve symptoms and improve a person's quality of life.

Support Groups

Cancer affects how you feel about yourself and your life. You can ease the stress of illness by joining a cancer support group. Sharing with others who have the same experiences and problems can help you feel less alone.

Ask your provider or the staff at the cancer treatment center to help you find a support group for people who have been diagnosed with uterine cancer.

Outlook (Prognosis)

Your prognosis depends on the type and stage of uterine sarcoma you had when treated. For cancer that has not spread, at least 2 out of every 3 people are cancer-free after 5 years. The number drops once the cancer has started to spread and becomes harder to treat.

Uterine sarcoma is often not found early, therefore, the prognosis is poor. Your provider can help you understand the outlook for your type of cancer.

Possible Complications

Complications may include:

When to Contact a Medical Professional

See your provider if you have any symptoms of uterine cancer.


Because the cause is unknown, there's no way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.

Review Date: 7/26/2018
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

This information should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. © 1997- 2007 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.